Nelson J C, Charney D S
Am J Psychiatry. 1981 Jan;138(1):1-13. doi: 10.1176/ajp.138.1.1.
The authors suggest that the common characteristics of various descriptions of major depressive illness--endogenous, endogenomorphic, psychotic, and melancholic--are an autonomous course, a need for biological treatment, and a presumed alteration in neurochemistry. The literature is reviewed to determine those symptoms which best characterize this syndrome. These symptoms may prove useful in developing valid diagnostic criteria for major depressive illness.
作者们认为，重度抑郁症的各种描述——内源性、内源性形态、精神病性和忧郁症——的共同特征是病程自主、需要生物治疗以及推测存在神经化学改变。对文献进行了综述，以确定最能表征该综合征的症状。这些症状可能有助于制定重度抑郁症有效的诊断标准。
