Mirin S M, Schatzberg A F, Creasey D E
Am J Psychiatry. 1981 Jan;138(1):87-9. doi: 10.1176/ajp.138.1.87.
Seven patients who had been maintained on tricyclic antidepressants developed signs of hypomania or mania shortly (two-seven days) after drug withdrawal. Three patients responded promptly to treatment with neuroleptics. One patient receiving lithium and three others who received no further drug treatment experienced more gradual resolution of symptoms. Tricyclic withdrawal is accompanied by changes in the turnover rate of individual neurotransmitters as well as by shifts in the equilibrium between various transmitter systems. These events may be accompanied by alterations in mood. Although relapse to depression is more common, hypomania or mania may also occur.
七名一直服用三环类抗抑郁药的患者在停药后不久（两到七天）出现轻躁狂或躁狂症状。三名患者对使用抗精神病药物的治疗反应迅速。一名服用锂盐的患者和另外三名未接受进一步药物治疗的患者症状缓解较为缓慢。三环类药物戒断伴随着个体神经递质周转率的变化以及各种递质系统之间平衡的改变。这些情况可能伴随着情绪的变化。虽然复发为抑郁更为常见，但也可能发生轻躁狂或躁狂。
