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高比放射性氚标记人β-内啡肽的制备及其性质

Preparation and properties of tritiated human beta-endorphin with high specific radioactivity.

作者信息

Houghten R A, Li C H

出版信息

Int J Pept Protein Res. 1978 Nov;12(5):325-6. doi: 10.1111/j.1399-3011.1978.tb02904.x.

DOI:10.1111/j.1399-3011.1978.tb02904.x
PMID:744691
Abstract

Tritiated human beta-endorphin, specifically labelled at Tyr27, has been prepared with 50 Ci/mmol. Various physicochemical investigations indicated that tritiated peptide is identical with the native betah-endorphin. In addition, opiate activity of the tritiated product possesses the same potency as the native peptide.

摘要

已制备出在酪氨酸27处特异性标记的氚化人β-内啡肽，其比活度为50居里/毫摩尔。各种物理化学研究表明，氚化肽与天然β-内啡肽相同。此外，氚化产物的阿片样物质活性与天然肽具有相同的效力。

相似文献

1
Preparation and properties of tritiated human beta-endorphin with high specific radioactivity.高比放射性氚标记人β-内啡肽的制备及其性质
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引用本文的文献

1
beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.β-内啡肽：大鼠和兔子静脉注射氚标记肽后的稳定性、清除行为及进入中枢神经系统的情况。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4588-91. doi: 10.1073/pnas.77.8.4588.
2
beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.β-内啡肽诱导的镇痛作用受到β-内啡肽合成类似物的抑制。
Proc Natl Acad Sci U S A. 1984 May;81(10):3074-7. doi: 10.1073/pnas.81.10.3074.
3
Characterization of beta-endorphin binding protein (receptor) from rat brain membranes.
大鼠脑膜中β-内啡肽结合蛋白（受体）的特性分析
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6494-6. doi: 10.1073/pnas.79.21.6494.
4
Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion.β-内啡肽：以氚标记的人激素和纳洛酮作为主要配体研究六种天然存在的β-内啡肽同系物的阿片受体结合活性——钠离子的影响
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2191-3. doi: 10.1073/pnas.79.7.2191.
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beta-Endorphin: characteristics of binding sites in a neuroblastoma--glioma hybrid cell.β-内啡肽：神经母细胞瘤-胶质瘤杂交细胞中结合位点的特征
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2218-20. doi: 10.1073/pnas.78.4.2218.
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beta-Endorphin: characteristics of binding sites in rabbit spinal cord.β-内啡肽：兔脊髓中结合位点的特征
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5746-8. doi: 10.1073/pnas.77.10.5746.
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beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities.β-内啡肽缺失类似物：免疫反应性与其他生物学活性的解离
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3211-4. doi: 10.1073/pnas.77.6.3211.
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Beta-Endorphin: dissociation of receptor binding activity from analgesic potency.β-内啡肽：受体结合活性与镇痛效力的解离。
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Proc Natl Acad Sci U S A. 1986 Jul;83(13):4622-5. doi: 10.1073/pnas.83.13.4622.
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Characterization of solubilized human and rat brain beta-endorphin-receptor complex.可溶性人及大鼠脑β-内啡肽受体复合物的特性鉴定
Proc Natl Acad Sci U S A. 1986 Jan;83(1):67-71. doi: 10.1073/pnas.83.1.67.