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[四环素片的质量与稳定性]

[Quality and stability of tetracycline tablets].

作者信息

Nesterova L Ia, Grakovskaia L K, Shadyro L L, Okhotnikova V F

出版信息

Antibiotiki. 1980 Nov;25(11):828-31.

PMID:7447399
Abstract

Tetracycline base tablets with dragee (sugar) and gastric soluble film coatings were investigated. Advantages of the tablets with the film coating in the main characteristics, such as bioavailability and levels of tetracycline-like admixtures were shown. The structure of the surface layer of the dragee coating was studied. It was found that the products contained in the coating and magnesium carbonate, in particular, lowered the tablet solubility.

摘要

对带有糖衣和胃溶性薄膜包衣的四环素碱片进行了研究。结果表明,薄膜包衣片在生物利用度和四环素类混合物水平等主要特性方面具有优势。研究了糖衣包衣表面层的结构。发现包衣中含有的产品,特别是碳酸镁,降低了片剂的溶解度。

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