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[盐酸四环素片的性质与稳定性]

[Properties and stability of tetracycline hydrochloride tablets].

作者信息

Nesterova L Ia, Donskaia N G, Shadyro L L, Grakovskaia L K

出版信息

Antibiotiki. 1978 Jan;23(1):62-6.

PMID:623449
Abstract

Three forms of tetracycline hydrochloride tablets were studied, i.e. the uncoated tablets, sugar-coated tablets and the tablets with gastric-soluble film coating. The film-coated tablets had advantages in the main quality characteristics, i.e. the contents of the tetracycline-like admixtures, the active substance and solubility rate. The possibility of the tablet stability investigation by the method of "accelerated aging" was shown.

摘要

对三种盐酸四环素片进行了研究,即素片、糖衣片和胃溶薄膜包衣片。薄膜包衣片在主要质量特性方面具有优势,即四环素类杂质含量、活性物质含量和溶出速率。展示了采用“加速老化”方法进行片剂稳定性研究的可能性。

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