患黄曲霉毒素中毒的雏鸡血浆、胆汁和肝脏中B族维生素及氨基酸浓度异常。
Abnormal concentrations of B vitamins and amino acids in plasma, bile, and liver of chicks with aflatoxicosis.
作者信息
Voigt M N, Wyatt R D, Ayres J C, Koehler P E
出版信息
Appl Environ Microbiol. 1980 Nov;40(5):870-5. doi: 10.1128/aem.40.5.870-875.1980.
Graded levels of aflatoxin fed to broiler chickens for 3 weeks decreased the levels of most B vitamins in plasma, bile, and liver and decreased all free and hydrolyzed amino acids from peptides in plasma. The levels of thiamine, riboflavin, vitamin B6, pantothenic acid, and choline decreased by more than 60% in bile; vitamin B6, pantothenic acid, and choline decreased by more than 49% in plasma; thiamine, vitamin B6, pantothenic acid, choline, folate, and niacin decreased by more than 19% in liver; and only bile and plasma levels of folate increased (78 and 12%, respectively) with a dietary level of 5 microgram of aflatoxin per g of feed. Plasma levels of cystine and cysteine, methionine, threonine, serine, and aspartic acid decreased by more than 37%, whereas valine, lysine, leucine, histidine, hydroxyproline, and alanine decreased by more than 9% with 2.5 microgram of aflatoxin per g of feed. The data suggest that aflatoxin interferes with the metabolism of B vitamins and amino acids in chicks. However, these changes may be measuring the effects of aflatoxin-induced hepatic necrosis.
给肉鸡喂食黄曲霉毒素3周，不同剂量的黄曲霉毒素降低了血浆、胆汁和肝脏中大多数B族维生素的水平，并降低了血浆中所有游离氨基酸和来自肽的水解氨基酸水平。胆汁中硫胺素、核黄素、维生素B6、泛酸和胆碱的水平下降超过60%；血浆中维生素B6、泛酸和胆碱的水平下降超过49%；肝脏中硫胺素、维生素B6、泛酸、胆碱、叶酸和烟酸的水平下降超过19%；每克饲料中黄曲霉毒素含量为5微克时，只有胆汁和血浆中的叶酸水平升高（分别为78%和12%）。每克饲料中黄曲霉毒素含量为2.5微克时，血浆中胱氨酸、半胱氨酸、蛋氨酸、苏氨酸、丝氨酸和天冬氨酸的水平下降超过37%，而缬氨酸、赖氨酸、亮氨酸、组氨酸、羟脯氨酸和丙氨酸的水平下降超过9%。数据表明，黄曲霉毒素会干扰雏鸡体内B族维生素和氨基酸的代谢。然而，这些变化可能反映的是黄曲霉毒素诱导的肝坏死的影响。
Zotero 插件