Viogt M N, Clarke J D, Jain A V, Ayres J C, Koehler P E, Hatch R C
Appl Environ Microbiol. 1981 Apr;41(4):919-23. doi: 10.1128/aem.41.4.919-923.1981.
The dosages of aflatoxin B1 (AFB1) required to produce significant changes in concentrations of B vitamins in plasma and bile and of amino acids in plasma of rabbits were determined. Folate increased by 98% in plasma, whereas concentration of thiamine, vitamin B6, and biotin decreased by more than 50%. In bile, choline and biotin increased 14- and 18-fold, respectively, whereas folate and niacin decreased by more than 50%. All amino acids in plasma increased between 76 and 155%. The dosages of AFB1 required to induce these changes were usually between 12.5 and 37.5 microgram/kg of body weight per day. Except for changes in biliary concentrations of pantothenic acid, folic acid, and biotin, lower threshold dosages of aflatoxin were required to produce weight loss and anorexia (5.0 and 8.5 microgram of AFB1/kg per day, respectively) than for changes in vitamins and amino acids (approximately 25 to 50 microgram of AFB1/kg per day). The data indicated that AFB1 interfered with the metabolism of B vitamins and amino acids in rabbits.
测定了黄曲霉毒素B1（AFB1）在兔血浆和胆汁中产生B族维生素浓度显著变化以及血浆中氨基酸浓度显著变化所需的剂量。血浆中叶酸增加了98%，而硫胺素、维生素B6和生物素的浓度下降了50%以上。在胆汁中，胆碱和生物素分别增加了14倍和18倍，而叶酸和烟酸下降了50%以上。血浆中所有氨基酸增加了76%至155%。诱导这些变化所需的AFB1剂量通常为每天12.5至37.5微克/千克体重。除了泛酸、叶酸和生物素的胆汁浓度变化外，产生体重减轻和厌食所需的黄曲霉毒素阈值剂量（分别为每天5.0和8.5微克AFB1/千克）低于产生维生素和氨基酸变化所需的剂量（约为每天25至50微克AFB1/千克）。数据表明，AFB1干扰了兔体内B族维生素和氨基酸的代谢。
