Zawoiski E J
Arch Int Pharmacodyn Ther. 1980 Sep;247(1):103-18.
The effects of norepinephrine HCl, isoproterenol HCl, phentolamine and 6-hydroxydopamine HCl on mean arterial blood pressure (MABP), heart rate (HR), and pulmonary respiration were examined in 67 urethane-anesthetized, spontaneously hypertensive rats (SHR) with carotid arterial and femoral venous catheters and stereotaxically positioned intracerebral cannulae. Norepinephrine produced significant pressor responses when it was instilled into the posterior hypothalamic region and/or the pars magnocellularis region of the ventral medial thalamus. Central pretreatment with either phentolamine mesylate or phentolamine HCl, 30 min before central administration of norepinephrine, blocked the norepinephrine-induced pressor responses. Central administration of 6-hydroxydopamine HCl in the hypothalamic-thalamic region of the diencephalon produced significant depressor responses within 60 min. Neither norepinephrine nor isoprotereol produced their centrally-induced pressor and depressor responses when they were instilled centrally into the reticular formation. The results suggest that receptors that respond to norepinephrine are located in the posterior hypothalamic-ventral medial thalamic region of the diencephalon. The results also suggest that cells located in these areas send projection fibers either directly or indirectly to the vasomotor center located in the brain stem.
在67只使用氨基甲酸乙酯麻醉、患有自发性高血压且已插入颈动脉和股静脉导管以及立体定位脑内插管的大鼠（SHR）中，研究了盐酸去甲肾上腺素、盐酸异丙肾上腺素、酚妥拉明和盐酸6-羟基多巴胺对平均动脉血压（MABP）、心率（HR）和肺呼吸的影响。当将去甲肾上腺素注入下丘脑后部区域和/或腹内侧丘脑的大细胞部区域时，会产生显著的升压反应。在向中枢给予去甲肾上腺素前30分钟，用甲磺酸酚妥拉明或盐酸酚妥拉明进行中枢预处理，可阻断去甲肾上腺素诱导的升压反应。在间脑的下丘脑 - 丘脑区域中枢给予盐酸6-羟基多巴胺，在60分钟内产生显著的降压反应。当将去甲肾上腺素和异丙肾上腺素注入中枢网状结构时，它们均未产生中枢诱导的升压和降压反应。结果表明，对去甲肾上腺素起反应的受体位于间脑的下丘脑后部 - 腹内侧丘脑区域。结果还表明，位于这些区域的细胞直接或间接向位于脑干的血管运动中枢发送投射纤维。
