Kubo T, Hashimoto M
Arch Int Pharmacodyn Ther. 1978 Mar;232(1):166-76.
Six-hydroxydopamine (6-OH-DA) was administered intraventricularly to 6-week-old and 5-month-old spontaneously hypertensive rats (SHR), and was administered into the spinal cord of 6-week-old SHR. Intraventricular administration of 6-OH-DA into 6-week-old SHR prevented the development of hypertension for at least 12 weeks; pressor response of the perfused hindquarters to noradrenaline was the same in 6-OH-DA-treated and vehicle-treated animals. Intraventricular administration of 6-OH-DA into 5-month-old SHR with established hypertension produced only a transient fall in blood pressure. Local injection of 6-OH-DA into the spinal cord produced a marked reduction only in spinal cord noradrenaline but did not affect the development of hypertension in SHR. These findings suggest that brain adrenergic neurons may participate in the development of hypertension in SHR but noradrenergic projections in the spinal cords are not essential for this process.
将6-羟基多巴胺（6-OH-DA）脑室内注射到6周龄和5月龄的自发性高血压大鼠（SHR）体内，并将其注射到6周龄SHR的脊髓中。对6周龄SHR进行6-OH-DA脑室内注射可使高血压至少12周不发展；在6-OH-DA处理组和溶剂处理组动物中，灌注后肢对去甲肾上腺素的升压反应相同。对已有高血压的5月龄SHR进行6-OH-DA脑室内注射仅使血压出现短暂下降。将6-OH-DA局部注射到脊髓中仅使脊髓中的去甲肾上腺素显著减少，但不影响SHR高血压的发展。这些发现表明，脑内肾上腺素能神经元可能参与了SHR高血压的发展，但脊髓中的去甲肾上腺素能投射对这一过程并非必不可少。
