Chauvel Y, Fernandez-Tello D S, Frommel D
Arch Fr Pediatr. 1980;37 Suppl 2:V-VII.
Liver-membrane auto-antibodies (LMA) were searched for in children with histologically proven chronic active hepatitis. LMA were found in the serum of all 20 patients under study. In the 6 cases associated with hepatitis B virus, LMA were the sole marker for auto-immunity; in 11 cases, negative for HBsAg, other anti-tissue antibodies, smooth muscle or endoplasmic reticulum antibody, coexisted. Neither prior to therapy nor during treatment with prednisone and azathioprine was there any correlation between titres of LMA and those of other auto-antibodies nor with the assessment of histological activity. Although a reliable diagnostic marker, LMA, as revealed by using heterologous hepatocytes, appear to convey limited values as a prognostic marker of chronic active hepatitis in children.
在组织学确诊为慢性活动性肝炎的儿童中检测肝膜自身抗体（LMA）。在所有20例研究对象的血清中均发现了LMA。在6例与乙型肝炎病毒相关的病例中，LMA是自身免疫的唯一标志物；在11例HBsAg阴性的病例中，还存在其他抗组织抗体、平滑肌或内质网抗体。在使用泼尼松和硫唑嘌呤治疗之前及治疗期间，LMA的滴度与其他自身抗体的滴度之间均无相关性，也与组织学活性评估无关。尽管LMA是一种可靠的诊断标志物，但通过使用异源肝细胞检测发现，其作为儿童慢性活动性肝炎预后标志物的价值似乎有限。
