Aptekar' S G, Vikhert A M, Matova E E, Galakhov I E, Kovalevskaia A L
Arkh Patol. 1980;42(10):45-50.
The study covered 114 men dying suddenly of coronary heart disease (CHD). Hypercholesterinemia was found in 43% of the cases, lowered cholesterol, high density lipoproteins or hypoalphacholesterolemia in 75%. Thus hypoalphacholesterolemia correlates with CHD more frequently than hypercholesterolemia. The area of lipoidosis in the aorta did not correlate with cholesterol levels in the blood plasma. The content of cholesterol in lipid spots is significantly higher in patients with a high cholesterol level in the blood plasma. The area of eminent lesions in the aorta was significantly greater in high cholesterol level in the blood plasma than in low or normal content. In patients with high cholesterol level in the blood multiple stenoses of coronary arteries were found more frequently and isolated stenoses less frequently than in subjects with low cholesterol levels. In the former, stenosis of coronary arteries always exceeded 50% of the vessel lumen while with low cholesterol levels the stenosis did not exceed 50% of the vessel lumen in 10.4% of cases.
该研究涵盖了114名因冠心病(CHD)突然死亡的男性。43%的病例存在高胆固醇血症,75%存在胆固醇降低、高密度脂蛋白降低或低α胆固醇血症。因此,低α胆固醇血症与冠心病的相关性比高胆固醇血症更为频繁。主动脉脂质沉着面积与血浆胆固醇水平无关。血浆胆固醇水平高的患者脂质斑点中的胆固醇含量显著更高。血浆胆固醇水平高时主动脉明显病变的面积显著大于低或正常含量时。血浆胆固醇水平高的患者与胆固醇水平低的受试者相比,冠状动脉多处狭窄更为常见,孤立性狭窄则较少见。在前者中,冠状动脉狭窄总是超过血管腔的50%,而胆固醇水平低时,10.4%的病例中狭窄不超过血管腔的50%。