自闭症与智力迟钝：对四名有自闭症行为的智力迟钝患者进行的神经病理学研究。

Autism and mental retardation: neuropathologic studies performed in four retarded persons with autistic behavior.

作者信息

Williams R S, Hauser S L, Purpura D P, DeLong G R, Swisher C N

出版信息

Arch Neurol. 1980 Dec;37(12):749-53. doi: 10.1001/archneur.1980.00500610029003.

DOI:10.1001/archneur.1980.00500610029003

Abstract

Four persons who exhibited prominent autistic features throughout life died when 4, 14, 27, and 33 years old. All were mentally retarded. One had documented phenylketonuria, but the cause of mental retardation and autistic behavior was undefined in three. At the time of autopsy, brain weights were within 2 SDs of the norm for age. Complete neuropathologic examination, including analysis of cortical neurons impregnated with the rapid Golgi method, failed to provide clues as to cause or the pathoanatomic substrate of autistic behavior in these cases.

摘要

四名终生表现出明显自闭症特征的人分别在4岁、14岁、27岁和33岁时死亡。他们均有智力障碍。其中一人被诊断患有苯丙酮尿症，但另外三人智力障碍和自闭症行为的病因不明。尸检时，脑重量在该年龄正常范围的2个标准差之内。全面的神经病理学检查，包括用快速高尔基方法对皮质神经元进行分析，未能为这些病例中自闭症行为的病因或病理解剖学基础提供线索。