Hashimoto T, Murakawa K, Miyazaki M, Tayama M, Kuroda Y
Department of Pediatrics, University of Tokushima School of Medicine, Japan.
Acta Paediatr. 1992 Dec;81(12):1030-4. doi: 10.1111/j.1651-2227.1992.tb12169.x.
Midsagittal magnetic resonance images of the brains of retarded autistic children were compared to those of non-autistic mental retardation patients and controls. We found that the whole brain stem and particularly two of its components (the midbrain and medulla oblongata) were significantly smaller in retarded autistic children and mental retardation cases than in control children. The pons area was significantly smaller in mental retardation cases as compared to control children but did not differ between autistic and control children. Moreover, there was no difference in the brain stem between retarded autistic children and mental retardation cases. We also noted no difference in the cerebellar vermis area among retarded autistic children, mental retardation cases and control children. The ratio of the midbrain to posterior fossa area was significantly smaller only in autistic patients. Although the significance of these results is unknown, further examination of autistic children with a normal IQ is necessary.
对智力发育迟缓的自闭症儿童的大脑正中矢状面磁共振图像与非自闭症智力发育迟缓患者及对照组进行了比较。我们发现，智力发育迟缓的自闭症儿童和智力发育迟缓病例的整个脑干，尤其是其中两个部分（中脑和延髓），比对照儿童明显更小。与对照儿童相比，智力发育迟缓病例的脑桥区域明显更小，但自闭症儿童与对照儿童之间没有差异。此外，智力发育迟缓的自闭症儿童与智力发育迟缓病例的脑干没有差异。我们还注意到，智力发育迟缓的自闭症儿童、智力发育迟缓病例和对照儿童的小脑蚓部区域没有差异。仅自闭症患者的中脑与后颅窝面积之比明显更小。尽管这些结果的意义尚不清楚，但有必要对智商正常的自闭症儿童进行进一步检查。
