Hirst L W, Quigley H A, Stark W J, Shields N B
Aust J Ophthalmol. 1980 May;8(2):139-46. doi: 10.1111/j.1442-9071.1980.tb01672.x.
Clinical specular microscopic examination of 17 patients with features common to the irido-corneal endothelial syndrome (including Chandler's syndrome, iris nevus syndrome, and essential iris atrophy) revealed pathognomonic endothelial changes and no areas of normal endothelial mosaic. Even in those patients with minimal anterior synechiae, gross central endothelial changes could be found, suggesting that the endothelial changes are primary and not secondary to the iris-corneal adhesions. Specular microscopy of the clinically-uninvolved contralateral eye in the patients revealed frequent endothelial-cell pleomorphism incommensurate with the patient's age. This study also confirmed the value of the specular microscopy in making qualitative endothelial observations.
对17例具有虹膜角膜内皮综合征（包括钱德勒综合征、虹膜痣综合征和原发性虹膜萎缩）共同特征的患者进行临床镜面显微镜检查，发现了具有诊断意义的内皮改变，且未见正常内皮镶嵌区域。即使在那些前粘连最少的患者中，也能发现明显的中央内皮改变，这表明内皮改变是原发性的，而非虹膜角膜粘连的继发性改变。对这些患者未受临床影响的对侧眼进行镜面显微镜检查，发现内皮细胞多形性频繁出现，与患者年龄不符。本研究还证实了镜面显微镜在进行内皮定性观察方面的价值。
