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[中心代谢途径的氧化还原与磷酸化平衡：正常大鼠肝脏以及二氯乙酸和苯乙双胍处理后（继二氯乙酸处理）的大鼠肝脏概况]

[Redox and phosphorylation equilibrium of the central metabolic pathway: rat liver profile in controls and after treatment with dichloroacetate and phenformin following dichloroacetate].

作者信息

Cingolani M L, Bastianelli P, Cannelli B, Salvucci M P

出版信息

Boll Soc Ital Biol Sper. 1980 May 30;56(10):1097-102.

PMID:7448013
Abstract

Glycolytic-, oxidative shunt, and mitochondrial metabolites, UDPG and high-energy-phosphates were measured in the liver of rats treated with Phenformin and/or Sodium Dichloroacetate. The substrate level profiles of the acute (90-60 min before sacrifice) treated groups were studied, and the interrelationships among substrate-coupled pyridine dependent dehydrogenase-redox potentials, the high energy-potentials of cytosolic and mitochondrial spaces, in the above-mentioned conditions, are discussed.

摘要

在接受苯乙双胍和/或二氯醋酸钠治疗的大鼠肝脏中，对糖酵解、氧化分流和线粒体代谢产物、尿苷二磷酸葡萄糖（UDPG）和高能磷酸盐进行了测定。研究了急性治疗组（处死前90 - 60分钟）的底物水平概况，并讨论了上述条件下底物偶联的吡啶依赖性脱氢酶-氧化还原电位、胞质和线粒体空间的高能电位之间的相互关系。

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