[Redox and phosphorylation equilibrium of the central metabolic pathway: rat liver profile in controls and after treatment with dichloroacetate and phenformin following dichloroacetate].

Glycolytic-, oxidative shunt, and mitochondrial metabolites, UDPG and high-energy-phosphates were measured in the liver of rats treated with Phenformin and/or Sodium Dichloroacetate. The substrate level profiles of the acute (90-60 min before sacrifice) treated groups were studied, and the interrelationships among substrate-coupled pyridine dependent dehydrogenase-redox potentials, the high energy-potentials of cytosolic and mitochondrial spaces, in the above-mentioned conditions, are discussed.