Loubatières A, Ribes G, Valette G, Lignon F, Rondot A M
C R Seances Soc Biol Fil. 1977;171(1):150-5.
In the normal anesthetized dog the combination of insulin, whether of exogenous or endogenous origin, with sodium dichloroacetate provoke a rapid and important reduction of the hyperlactatemia and hyperpyruvicemia induced by the intraduodenal injection of high doses of phenformin. Furthermore this combination prevents the progressive and important lowering of the arterial pH provoked by phenformin.
在正常麻醉犬中，胰岛素（无论外源性还是内源性）与二氯醋酸钠联合使用，可迅速且显著降低十二指肠内注射大剂量苯乙双胍所诱导的高乳酸血症和高丙酮酸血症。此外，这种联合用药可防止苯乙双胍引起的动脉血pH值逐渐且显著下降。
