Santa Cruz D J, Reiner C B
J Cutan Pathol. 1978 Dec;5(6):339-46. doi: 10.1111/j.1600-0560.1978.tb00963.x.
Four cases of recurrent digital fibroma of childhood are presented, bringing the total of reported cases to 79. From our material and a review of the literature, the most characteristic features of this entity are delineated. There is no predilection for either sex. Seventy-three percent (58 cases) occurred under one year of age with 14 observed at birth; only four patients were over 5-years-old and the oldest was 15. The localization is highly diagnostic, being limited to the second to fifth carpal and pedal digits and no reported involvement of thumbs or great toes. Two cases were observed in the sole and ulnar side of the hand but associated with others in classical locations. In 50% of cases, the lesions are single at the time of diagnosis. The recurrence rate, based upon cases with adequate follow-up, was found to be 75%. To our knowledge no metastasis has ever been reported. The histology is that of well-differentiated fibroblastic tumor with pathognomonic eosinophilic cytoplasmic inclusion bodies. A review of the available electron microscopic data is presented and the histogenesis is discussed.
本文报告了4例儿童复发性指状纤维瘤，使报告病例总数达到79例。根据我们的资料和文献回顾，描述了该疾病最典型的特征。该疾病无性别倾向。73%（58例）发生在1岁以下，其中14例在出生时即被观察到；仅有4例患者年龄超过5岁，年龄最大的为15岁。其定位具有高度诊断性，局限于第二至第五腕指和足趾，尚无拇指或拇趾受累的报告。有2例在手掌尺侧和足底被观察到，但同时伴有其他典型部位的病变。在50%的病例中，诊断时病变为单发。根据有充分随访的病例，复发率为75%。据我们所知，从未有过转移的报告。组织学表现为分化良好的成纤维细胞肿瘤，具有特征性的嗜酸性细胞质包涵体。本文还对现有的电子显微镜数据进行了综述，并讨论了组织发生。
