Crocker B D, Okumura F, McCuaig D I, Denborough M A
Br J Anaesth. 1980 Dec;52(12):1223-9. doi: 10.1093/bja/52.12.1223.
A study of core temperature monitoring during general anesthesia indicates that this can be introduced as a routine procedure in order to reduce mortality from malignant hyperpyrexia. The temperature profiles of 2410 patients are presented. Both mean rectal and mean oesophageal temperatures decreased during general anaesthesia. The mean oesophageal temperatures were on average 0.6 degrees C less than the mean rectal temperatures during the first hour of anaesthesia. An increase in core temperature occurred in nearly 20% of patients. This appeared to be related to an initially low body temperature. Core temperatures during general anesthesia were significantly greater in patients who received the combination of suxamethonium and halothane than in patients receiving other drugs. This observation is of theoretical interest and suggests that the increase of temperature in malignant hyperpyrexia may be an exaggeration of a normal response to these agents.
一项关于全身麻醉期间核心体温监测的研究表明，为降低恶性高热导致的死亡率，可将其作为常规程序引入。文中呈现了2410名患者的体温曲线。全身麻醉期间，直肠平均温度和食管平均温度均下降。麻醉的第一个小时内，食管平均温度平均比直肠平均温度低0.6摄氏度。近20%的患者出现核心体温升高。这似乎与最初体温较低有关。接受琥珀酰胆碱和氟烷联合用药的患者在全身麻醉期间的核心体温显著高于接受其他药物的患者。这一观察结果具有理论意义，表明恶性高热时体温升高可能是对这些药物正常反应的过度表现。
