Caillé G, Besner J G, Lacasse Y, Vézina M
Biopharm Drug Dispos. 1980 Apr-Jun;1(4):187-94. doi: 10.1002/bdd.2510010406.
A sensitive and specific gas chromatographic method using a nitrogen detector for the measurement of trimipramine plasma concentrations is described. This method was used to determine the relative bioavailability and some pharmacokinetic parameters of two formulations, tablets and capsules, in healthy volunteers. It was concluded the tablet and capsule formulations were pharmacokinetically equivalent.
本文描述了一种使用氮检测器的灵敏且特异的气相色谱法，用于测定三甲丙咪嗪的血浆浓度。该方法用于确定两种制剂（片剂和胶囊）在健康志愿者中的相对生物利用度和一些药代动力学参数。得出的结论是片剂和胶囊制剂在药代动力学上等效。
