由具有抗-Pr特异性的单克隆IgG冷凝集素引起的慢性溶血性贫血。
Chronic hemolytic anemia due to a monoclonal IgG cold agglutinin with anti-Pr specificity.
作者信息
Dellagi K, Brouet J C, Schenmetzler C, Praloran V
出版信息
Blood. 1981 Jan;57(1):189-91.
PMID:7448411
Abstract
Immunologic studies performed in a case of autoimmune chronic hemolytic anemia with low titer cold agglutinins (1/16) demonstrated that the cold agglutinins corresponded to monoclonal IgG with anti-Pr specificity. This antibody had a large thermal amplitude, being active at 37 degrees C. These unusual characteristics may define a distinct subset of chronic cold agglutinin disease.
摘要
在一例伴有低滴度冷凝集素（1/16）的自身免疫性慢性溶血性贫血病例中进行的免疫学研究表明，冷凝集素对应于具有抗-Pr特异性的单克隆IgG。该抗体具有较大的热幅度，在37℃时具有活性。这些不寻常的特征可能定义了慢性冷凝集素病的一个独特亚组。
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