Wortman J, Rosse W, Logue G
Am J Hematol. 1979;6(3):275-83. doi: 10.1002/ajh.2830060312.
Four patients with nonhematologic malignancies had the simultaneous finding of hemolytic anemia due to high-titer cold agglutinins. In each patient, the cold agglutinin had "anti-I" specificity and was of the IgM kappa immunoglobulin class. Although patients with hematologic malignancies not uncommonly have cold agglutinins, the association between these antibodies and nonhematologic malignancies is unusual.
四名非血液系统恶性肿瘤患者同时出现了由于高效价冷凝集素导致的溶血性贫血。在每例患者中，冷凝集素具有“抗-I”特异性，且属于IgM κ免疫球蛋白类别。虽然血液系统恶性肿瘤患者中出现冷凝集素并不罕见，但这些抗体与非血液系统恶性肿瘤之间的关联并不常见。
