Meadows A T, Strong L C, Li F P, D'Angio G J, Schweisguth O, Freeman A I, Jenkin R D, Morris-Jones P, Nesbit M E
Cancer. 1980 Dec 15;46(12):2603-6. doi: 10.1002/1097-0142(19801215)46:12<2603::aid-cncr2820461212>3.0.co;2-4.
Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors wer present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two-mutation hypothesis. Studies of SMN in childhood permit us to make observation about the role of genetic factors and environmental mutagens in cancer etiology.
骨肉瘤或软骨肉瘤作为第二原发性恶性肿瘤（SMN）出现在188例童年时期首次发生肿瘤的SMN患者中的40例。在23例中发现了癌症遗传易感性；32例的SMN发生在放疗区域；16例同时存在这两个因素；1例两者皆无。当存在遗传易感性时，放疗缩短了发生SMN的间隔时间。根据双突变假说分析了肿瘤之间的间隔时间以及骨肉瘤发生时与遗传疾病和治疗相关的年龄。对儿童期SMN的研究使我们能够观察遗传因素和环境诱变剂在癌症病因学中的作用。
