Bender J W
Cancer Biochem Biophys. 1980;4(4):233-6.
VP 16-213, an antineoplastic, semisynthetic podophyllotoxin derivative, inhibits NBT reduction in the polymorphonuclear neutrophil (PMN). In the resting PMN an almost complete inhibition is seen at a concentration of 170 microM and a partial inhibition is seen at 17 microM. In PMN's stimulated with zymosan activated serum, partial inhibition is seen at concentrations of both 170 microM and 17 microM. VP 16-213 shows no significant inhibition of NBT reduction in PMN's stimulated by methylene blue. VP 16-213 may alter normal respiratory function in the PMN as reflected by inhibition of NBT reduction.
VP 16 - 213是一种抗肿瘤的半合成鬼臼毒素衍生物，可抑制多形核中性粒细胞（PMN）中的NBT还原。在静息的PMN中，浓度为170微摩尔时几乎完全抑制，17微摩尔时部分抑制。在用酵母聚糖激活血清刺激的PMN中，170微摩尔和17微摩尔浓度时均出现部分抑制。VP 16 - 213对亚甲蓝刺激的PMN中的NBT还原无明显抑制作用。VP 16 - 213可能通过抑制NBT还原改变PMN中的正常呼吸功能。
