Janssens J P, Wittevrongel C, Van Dam J, Goddeeris P, Lauwerijns J M, De Loecker W
Cancer Res. 1981 Feb;41(2):703-7.
The determination of estradiol and progesterone receptor concentrations in mammary tumors is useful in predicting the hormone responsiveness. As this assay is carried out on tumor tissue which may have been subjected to radiotherapy, the possibility of an ionizing irradiation affecting the steroid receptor levels in neoplastic tissue should be taken into account. The steroid receptor concentrations are examined in dimethylbenz(a)anthracene-induced tumors of Sprague-Dawley rats. The estradiol and the progesterone receptor titers become reduced significantly after treatment with 20 Gray while an application with 7 Gray does not affect the titer values. After treatment of the tumor with 20 Gray, the steroid receptor concentrations decrease progressively, reaching a maximal reduction 20 to 30 days after exposure. This measured reduction in binding sites seems to be the result of a specific irradiation effect and not due to a possible increase in lytic enzyme levels in the regressing tumors. As radiation treatment affects the receptor concentrations, this should be kept in mind when interpreting the steroid receptor concentrations.
测定乳腺肿瘤中雌二醇和孕酮受体浓度有助于预测激素反应性。由于该检测是在可能接受过放疗的肿瘤组织上进行的，因此应考虑电离辐射影响肿瘤组织中类固醇受体水平的可能性。在Sprague-Dawley大鼠经二甲基苯并(a)蒽诱导的肿瘤中检测类固醇受体浓度。用20戈瑞处理后，雌二醇和孕酮受体滴度显著降低，而用7戈瑞处理则不影响滴度值。用20戈瑞处理肿瘤后，类固醇受体浓度逐渐降低，在照射后20至30天达到最大降幅。这种结合位点的测量降幅似乎是特定辐射效应的结果，而非由于消退肿瘤中裂解酶水平可能增加所致。由于放射治疗会影响受体浓度，因此在解释类固醇受体浓度时应牢记这一点。
