Haq M M, Legha S S, Samaan N A, Bodey G P, Burgess M A
Cancer Treat Rep. 1980 Aug-Sep;64(8-9):909-13.
Adrenal cortical carcinoma is a rare tumor with a poor prognosis. Experience with chemotherapy in this tumor besides mitotane is practically nonexistent. We are reporting the results of 27 trials of various chemotherapeutic regimens among 12 patients with metastatic disease. Most patients (nine of 12) had a trial of mitotane before cytotoxic drugs were instituted. Three patients achieved a partial remission, one achieved a minor regression, and three had stable disease. All of the responses were of short duration. Alkylating agents and doxorubicin appear to have some antitumor activity. Multi-institutional cooperative studies are needed to detect active drugs and drug combinations against this neoplasm.
肾上腺皮质癌是一种罕见的肿瘤，预后较差。除米托坦外，针对该肿瘤的化疗经验几乎不存在。我们报告了12例转移性疾病患者接受27次各种化疗方案试验的结果。大多数患者（12例中的9例）在开始使用细胞毒性药物之前接受了米托坦试验。3例患者实现部分缓解，1例实现轻度消退，3例病情稳定。所有反应持续时间均较短。烷化剂和阿霉素似乎具有一定的抗肿瘤活性。需要开展多机构合作研究来检测针对这种肿瘤的活性药物和药物组合。
