Murawaki Y, Hirayama C
Clin Chim Acta. 1980 Nov 20;108(1):121-8. doi: 10.1016/0009-8981(80)90300-9.
Human hepatic collagenolytic cathepsin consisted of a major component having a molecular weight of 25 000 and a minor one of 35 000; the former is indistinguishable for cathepsin B in its enzymatic properties. Hepatic collagenolytic cathepsin increased in chronic active liver disease in proportion to hepatic hydroxyproline content. The ratio of collagenolytic cathepsin to hepatic hydroxyproline content remained within the normal range in chronic hepatitis, but decreased significantly in cirrhosis. These results suggest that collagenolytic cathepsin participates, at least partly, in the progress of hepatic fibrosis.
人肝胶原分解组织蛋白酶由分子量为25000的主要成分和分子量为35000的次要成分组成；前者在酶学性质上与组织蛋白酶B无法区分。肝胶原分解组织蛋白酶在慢性活动性肝病中与肝羟脯氨酸含量成比例增加。在慢性肝炎中，胶原分解组织蛋白酶与肝羟脯氨酸含量的比值保持在正常范围内，但在肝硬化中显著降低。这些结果表明，胶原分解组织蛋白酶至少部分参与了肝纤维化的进展。
