The effects of meclofenamate on renal and peripheral vascular beds in conscious rabbits.
作者信息
Banks R A, Beilin L H, Soltys J S
出版信息
Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):531-4. doi: 10.1111/j.1440-1681.1980.tb00105.x.
Abstract
- Meclofenamate caused a dose-dependent increase in renovascular resistance in conscious rabbits. 2. This effect was greatest in inner cortical zones at the highest dose (6 mg/kg) but at the lowest dose (0.75 mg/kg) vascular resistance in the outer cortex was preferentially increased. 3. In contrast, meclofenamate increased cerebral perfusion and the proportion of cardiac output received by the testis. No effect was demonstrated on other organs studied. 4. The results suggest a local vasodilator influence of renal prostaglandins in normal conscious rabbits.
摘要
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