大鼠实验性高血压中的心肌梗死：血压降低机制

Myocardial infarction in experimental hypertension in rats: mechanism of the reduction in blood pressure.

Fletcher P J, Pfeffer J M, Pfeffer M A, Braunwald E

Clin Sci (Lond). 1980 Dec;59 Suppl 6:385s-387s. doi: 10.1042/cs059385s.

Abstract

Haemodynamic changes during graded methoxamine infusion have been measured in 16 spontaneously hypertensive rats with healed myocardial infarction produced by left coronary artery ligation and in 15 hypertensive rats without infarction. 2. Arterial pressure of the hypertensive rats was reduced to levels within the normotensive range in animals with moderate and large myocardial infarctions. 3. The peripheral vascular response to methoxamine was similar in rats with and without infarction. 4. The reduction in blood pressure resulted from a combination of lower heart rate and inability to maintain stroke volume at hypertensive pressures.

摘要

对16只通过左冠状动脉结扎产生愈合性心肌梗死的自发性高血压大鼠以及15只无梗死的高血压大鼠，测量了静脉输注不同剂量美速胺过程中的血流动力学变化。2. 在有中度和大面积心肌梗死的动物中，高血压大鼠的动脉血压降至正常血压范围内。3. 有梗死和无梗死的大鼠对美速胺的外周血管反应相似。4. 血压降低是由于心率降低以及在高血压水平下无法维持每搏量共同作用的结果。