左/右心室重量比：“心脏对高血压适应情况”的一种评估指标

Left/right ventricular weight ratio: an estimate of 'cardiac adaptation to hypertension'.

Hallbäck-Nordlander M

Clin Sci (Lond). 1980 Dec;59 Suppl 6:415s-417s. doi: 10.1042/cs059415s.

Abstract

Left and right ventricular weights were determined in newborn, 6, 15 and 28 week-old spontaneously hypertensive and normotensive control rats. 2. Left and right ventricles were heavier in all spontaneously hypertensive rats than in age-matched control rats, but the left/right ventricular weight ratio was increased only in 15 and 28 week-old spontaneously hypertensive rats. 3. If the cardiomegaly in newborn spontaneously hypertensive rats, in which the two ventricles have worked in parallel until birth, is an adaptation to hypertension in utero, left ventricular weight would rapidly increase after birth as the left ventricle alone is then exposed to an increased pressure. As left/right ventricular weight ratio was not increased in 6 week-old spontaneously hypertensive rats, factors other than hypertension may stimulate cardiac growth in the foetal spontaneously hypertensive rat. 4. This implies an initial structural 'resetting' of the cardiovascular dimensions in spontaneously hypertensive rats and that true pressure-dependent adaptation further potentiates these alterations in cardiovascular structure once hypertension is initiated.

摘要

测定新生、6周龄、15周龄和28周龄自发性高血压大鼠及正常血压对照大鼠的左、右心室重量。2. 所有自发性高血压大鼠的左、右心室均比年龄匹配的对照大鼠重，但仅15周龄和28周龄的自发性高血压大鼠的左/右心室重量比增加。3. 如果新生自发性高血压大鼠（其两个心室在出生前一直并行工作）的心脏肥大是对子宫内高血压的一种适应，那么出生后随着左心室单独承受升高的压力，左心室重量会迅速增加。由于6周龄自发性高血压大鼠的左/右心室重量比未增加，除高血压外的其他因素可能刺激胎儿自发性高血压大鼠的心脏生长。4. 这意味着自发性高血压大鼠心血管尺寸存在初始结构“重置”，并且一旦高血压开始，真正的压力依赖性适应会进一步增强这些心血管结构改变。