Halter F, Barbezat G O, van Hoorn-Hickman R, van Hoorn W A
Dig Dis Sci. 1980 Dec;25(12):916-20. doi: 10.1007/BF01308041.
Previous studies in man and preliminary experiments in the pig suggested an exponential healing rate for both gastric ulcers and induced mucosal defects. This was further investigated in six pigs with histamine-induced hyperacidity and in six controls. Healing of simple surgical defects measuring approximately 1.5 cm was endoscopically monitored at 2- to 3-day intervals through a Thomas cannula. In the control animals the healing rate was not strictly exponential but conformed to an organic decay curve with maximum healing phase around the fifth day and a slow initial and late healing velocity. In the six histamine-treated animals the healing rate was significantly delayed (P < 0.02) in the first four days but thereafter resembled that of the control animals. This suggests that acid secretion may be a determinant factor, especially within the early healing phase.
先前对人类的研究以及在猪身上进行的初步实验表明，胃溃疡和诱发的黏膜缺损均呈现指数愈合率。在六只因组胺诱发胃酸过多的猪和六只对照猪身上对此进行了进一步研究。通过托马斯套管，每隔2至3天对大小约为1.5厘米的单纯手术缺损的愈合情况进行内镜监测。在对照动物中，愈合率并非严格呈指数形式，而是符合有机衰减曲线，在第五天左右达到最大愈合阶段，初期和后期愈合速度较慢。在六只接受组胺治疗的动物中，前四天愈合率显著延迟（P < 0.02），但此后与对照动物相似。这表明胃酸分泌可能是一个决定性因素，尤其是在愈合早期阶段。
