利用离体兔心冠状动脉灌注法研究丙酮的体外毒性。

In-vitro toxicity of acetone using coronary perfusion in isolated rabbit heart.

作者信息

Raje R R

出版信息

Drug Chem Toxicol. 1980;3(3):333-42. doi: 10.3109/01480548009002227.

Abstract

In-vitro toxicity of acetone using isolated rabbit heart is reported. The hearts were perfused using Langendorf's procedure and modified Anderson's coronary perfusion apparatus. Heart rate and force of contraction were recorded mechanically and the coronary flow was measured manually. The force of contraction was significantly reduced; heart rate and coronary flow were significantly increased with acetone concentrations of 0.5% and 1.0% V/V.

摘要

报告了使用离体兔心脏对丙酮进行的体外毒性研究。采用Langendorf法和改良的Anderson冠状动脉灌注装置对心脏进行灌注。通过机械方式记录心率和收缩力，并手动测量冠状动脉血流量。当丙酮浓度为0.5%和1.0%（V/V）时，收缩力显著降低，心率和冠状动脉血流量显著增加。