Paterna S, Di Pasquale P, Antona A, D'Amico C, Bucca V, Arrostuto A, Palazzoadriano M, Licata G
Department of Internal Medicine, University of Palermo, Italy.
Drugs Exp Clin Res. 1995;21(1):37-40.
Sumatriptan provokes, in healthy subjects as well as in those who suffer from hemicrania, a slight increase in both systolic and diastolic arterial pressure. It has also been shown to increase the pressure of pulmonary circulation and to reduce the calibre of coronary arteries. The present investigation was undertaken to study the effects of sumatriptan (75 ng/l) on isolated rabbit hearts. Fifteen isolated rabbit hearts, perfused according to Langerdoff's procedure, were divided into two groups: Group I (5 hearts), perfused with Krebs-Henseleit solution, as a control, and Group II (10 hearts), perfused with Krebs-Henseleit mixed with sumatriptan succinate (75 ng/l). After 30 min of perfusion, the basal values of heart rate (HR) dp/dt, systolic ventricular pressure (SVP), diastolic ventricular pressure (DVP) and coronary flow (CF) were measured. The above values in either control or treated hearts were measured 5, 15, 30, 45, 60 min after recording the baseline values. HR, SVP, DVP, dp/dt and CF did not show significant differences in the two groups. The present data suggest that sumatriptan does not exert any action on isolated rabbit hearts.
舒马曲坦在健康受试者以及偏头痛患者中，会使动脉收缩压和舒张压均略有升高。研究还表明，它会增加肺循环压力并减小冠状动脉管径。本研究旨在探讨舒马曲坦（75纳克/升）对离体兔心的影响。按照朗格多夫法灌注的15个离体兔心被分为两组：第一组（5个心脏）用克雷布斯 - 亨泽莱特溶液灌注作为对照，第二组（10个心脏）用混合了琥珀酸舒马曲坦（75纳克/升）的克雷布斯 - 亨泽莱特溶液灌注。灌注30分钟后，测量心率（HR）、dp/dt、心室收缩压（SVP）、心室舒张压（DVP）和冠状动脉血流量（CF）的基础值。在记录基线值后的5、15、30、45、60分钟测量对照组或处理组心脏的上述值。两组的HR、SVP、DVP、dp/dt和CF均未显示出显著差异。目前的数据表明，舒马曲坦对离体兔心没有任何作用。
