Action of prostaglandin E1 and F2 alpha on the pinocytic activity of horseradish peroxidase in bone-marrow derived macrophages.

The influence of prostaglandin E1 and F2 alpha on the pinocytic activity of bone-marrow macrophages was studied biochemically and morphometrically. The results show that prostaglandin E1 induces 44% inhibition of pinocytosis of horseradish peroxidase; prostaglandin F2 alpha has no significant effect. Morphometrical analysis of electron micrographs demonstrates that inhibition of pinocytosis is connected with diminished average size and raised number of pinocytic vesicles. The influence of prostaglandin E1 on pinocytosis is fully reversible. Further experiments are needed to explore the molecular mechanism of the prostaglandin E1 induced alteration of membrane function.