Madsen E B, Rasmussen S, Svendsen T L
Eur J Cardiol. 1980;11(6):435-43.
From a symptom-limited bicycle exercise test 3 wk after acute myocardial infarction is 205 patients the prognostic significance for the 1-yr prognosis of the following variables was examined by a multivariate analysis (Cox's model): reasons for stopping, duration of work, maximal heart rate, maximal product heart rate x systolic blood pressure, maximal ST-deviation, time to maximal ST-deviation and ventricular ectopic beats (type and frequency). The reason for stopping was fatigue in 59% and angina pectoris in 15%. 48% exercised up to 6 min and 14% beyond 12 min with median duration of 7 min. The maximal heart rate was over 140/min in 30%. ST-deviations were found in 77%; in most patients below 3 mm. 44% had ventricular ectopic beats during the exercise. The only significant variable was the duration of of work with prognostic index for the 1-yr prognosis SE: SE = 1.21-0.16 x (duration of work). A probability of survival of over 0.95 after 1 yr required a duration of work over 13 min. The observed deaths were in good accordance with the expected with a little overestimation. 75% died from a definite cardial cause. There is a good predictive value for the 1-yr prognosis of the duration of work from an exercise test 3 wk after AMI.
在急性心肌梗死后3周,对205例患者进行了症状限制性自行车运动试验,通过多因素分析(Cox模型)研究了以下变量对1年预后的预后意义:停止运动的原因、运动持续时间、最大心率、最大心率×收缩压乘积、最大ST段压低、出现最大ST段压低的时间以及室性早搏(类型和频率)。停止运动的原因中,59%是疲劳,15%是心绞痛。48%的患者运动持续时间达6分钟,14%的患者超过12分钟,运动持续时间中位数为7分钟。30%的患者最大心率超过140次/分钟。77%的患者出现ST段压低;大多数患者压低幅度小于3毫米。44%的患者在运动期间出现室性早搏。唯一具有显著意义的变量是运动持续时间,其1年预后的预后指数为SE:SE = 1.21 - 0.16×(运动持续时间)。1年后生存率超过0.95需要运动持续时间超过13分钟。观察到的死亡情况与预期情况基本相符,略有高估。75%的患者死于明确的心脏原因。急性心肌梗死后3周进行运动试验所测得的运动持续时间对1年预后具有良好的预测价值。