Turkkan J S, Hienz R D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Psychopharmacology (Berl). 1990;100(1):124-9. doi: 10.1007/BF02245802.
Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Choice reaction times increased by 191 ms over baseline at the 0.68 mg/kg dose. Choice reaction times above the 95th percentile (i.e., the slowest reaction times) were the most slowed by nifedipine. Accuracy of color matching was decreased at 0.20 and 0.68 mg/kg by an average range of 2-4%. The yellow and white stimuli were the most difficult to discriminate correctly, and were also the most impaired by nifedipine. Nifedipine's behavioral effects were not modulated by blood pressure changes because daily changes in choice reaction time and systolic blood pressure were not correlated, and hypertensive status did not determine the behavioral effects. Potential sources of nifedipine's behavioral performance effects are discussed, with blood pressure changes excluded as a probable mechanism.
在给正常血压和高血压成年雄性狒狒长期口服硝苯地平之前、期间和之后，对其行为表现进行了测试。在三种给药方案（0.20、0.68和1.14毫克/千克/天）以及给予赋形剂期间，测量了它们在一项五色同时样品匹配任务中的表现。每种剂量连续给药21天，给药前后分别有14天的基线期和恢复期。在0.68毫克/千克剂量时，选择反应时间比基线增加了191毫秒。硝苯地平使高于第95百分位数的选择反应时间（即最慢的反应时间）减慢得最多。在0.20和0.68毫克/千克剂量时，颜色匹配的准确性平均降低了2 - 4%。黄色和白色刺激最难正确辨别，并且也受硝苯地平影响最大。硝苯地平的行为效应不受血压变化的调节，因为选择反应时间的每日变化与收缩压不相关，并且高血压状态也不能决定行为效应。本文讨论了硝苯地平行为表现效应的潜在来源，排除了血压变化作为可能机制。
