Bach M L, Bach F H, Zarling J M
Lancet. 1978 Jan 7;1(8054):20-2. doi: 10.1016/s0140-6736(78)90364-1.
It is proposed that cells cytotoxic for autologous or syngeneic tumour cells can be produced in vitro by sensitisation of lymphocytes to a pool of normal cells from 20 unrelated individuals. Restriction on molecules that can serve as cytotoxic determinants (C.D.), may explain why a random pool of cells from 20 people could present essentially all of the determinants (C.D.) may explain why a random pool of occur because of extensive cross-reactivity of antigens on tumour cells with normal alloantigens present in the stimulating pool.
有人提出，通过使淋巴细胞对来自20个无关个体的正常细胞池致敏，可在体外产生对自体或同基因肿瘤细胞具有细胞毒性的细胞。对可作为细胞毒性决定簇（C.D.）的分子的限制，可能解释了为什么来自20个人的随机细胞池能够呈现基本上所有的决定簇（C.D.），这可能是由于肿瘤细胞上的抗原与刺激池中存在的正常同种异体抗原具有广泛的交叉反应性所致。
