淋巴细胞对混合同种异体细胞的致敏作用。I. 对自体人淋巴母细胞系产生细胞毒性作用。
Sensitization of lymphocytes against pooled allogeneic cells. I. Generation of cytotoxicity against autologous human lymphoblastoid cell lines.
作者信息
Zarling J M, Bach F H
出版信息
J Exp Med. 1978 May 1;147(5):1334-40. doi: 10.1084/jem.147.5.1334.
Abstract
Lymphocytes sensitized in vitro to a pool of X-irradiated allogeneic normal lymphocytes from 20 individuals develop cytotoxic activity for autologous human lymphoblastoid cells (LCL). Whereas pool sensitized T lymphocytes lyse autologous LCL cells, they fail to lyse autologous B-enriched or T-enriched normal target cells nor autologous phytohemagglutinin (PHA) blasts. In contrast to pool sensitization, stimulation with normal cells of single allogeneic individuals rarely led to development of cytotoxicity against autologous LCL cells. We conclude that human Epstein-Barr virus transformed LCL cells express target antigens cross-reactive with allogeneic target antigens expressed on normal cells and that sensitization with a pool of allogeneic cells is an effective means of generating effector cells directed against autologous abnormal cells.
摘要
在体外对来自20个个体的经X射线照射的同种异体正常淋巴细胞池致敏的淋巴细胞，会对自体人淋巴母细胞样细胞（LCL）产生细胞毒性活性。虽然经池致敏的T淋巴细胞能裂解自体LCL细胞，但它们不能裂解自体富含B细胞或富含T细胞的正常靶细胞，也不能裂解自体植物血凝素（PHA）刺激的细胞。与池致敏相反，用单个同种异体个体的正常细胞刺激很少导致针对自体LCL细胞的细胞毒性的产生。我们得出结论，人爱泼斯坦-巴尔病毒转化的LCL细胞表达与正常细胞上表达的同种异体靶抗原交叉反应的靶抗原，并且用同种异体细胞池致敏是产生针对自体异常细胞的效应细胞的有效手段。
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