Güngör M, Genç E, Sağduyu H, Eroğlu L, Koyuncuoğlu H
Experientia. 1980 Nov 15;36(11):1309-10. doi: 10.1007/BF01969606.
The effect of 3 different doses of chronically-administered morphine on the primary immune response was studied in mice by estimating spleen/body weight ratio and serum hemolysin production against sheep red blood cells (SRBC). It was observed that morphine exerted a dose-dependent inhibitory effect on the immune response which was antagonized by the concomitant administration of naloxone. The findings suggest that the inhibitory effect of morphine is specific.
通过估算小鼠脾脏与体重之比以及针对绵羊红细胞（SRBC）的血清溶血素生成情况，研究了3种不同剂量长期给予吗啡对小鼠初次免疫反应的影响。观察到吗啡对免疫反应产生剂量依赖性抑制作用，而纳洛酮的同时给药可拮抗这种作用。这些发现表明吗啡的抑制作用具有特异性。
