Luik A I, Novikova N V
Farmakol Toksikol. 1980 Sep-Oct;43(5):593-7.
Study of embichin binding to human serum albumin in vitro by gel chromatography and fluorescence has shown that embichin is bound to human serum albumin with an association constant of 3.3 x 10(3) M-1. Interaction of embichin and albumin, that is reversible in the initial stages, transforms to irreversible on long-term contact of the protein with the drug. Experiments with cell culture indicate that the interaction with albumin potentiates the cytotoxic action of embichin.
通过凝胶色谱法和荧光法对土荆皮乙酸与人血清白蛋白体外结合的研究表明，土荆皮乙酸与人血清白蛋白结合的缔合常数为3.3×10³ M⁻¹。土荆皮乙酸与白蛋白的相互作用在初始阶段是可逆的，但在蛋白质与药物长期接触后会转变为不可逆。细胞培养实验表明，与白蛋白的相互作用增强了土荆皮乙酸的细胞毒性作用。
