血红蛋白A1c带在等电聚焦中的异质性。
Heterogeneity of the haemoglobin-A1c-band in isoelectric focussing.
作者信息
Welinder B S, Svendsen P A
出版信息
Diabetologia. 1980 Nov;19(5):465-7. doi: 10.1007/BF00281827.
PMID:7450320
Abstract
A double HbA1c-band was demonstrated in isoelectric focussing of blood from diabetics with a fasting blood glucose above 11 mmol/l. The same band-doubling was also demonstrated after incubation of erythrocytes in glucose/saline solutions. This finding may reflect the presence of the initial condensation product between haemoglobin and glucose, the Schiff-base intermediate.
摘要
在空腹血糖高于11 mmol/l的糖尿病患者血液的等电聚焦中显示出双条HbA1c带。在红细胞于葡萄糖/盐溶液中孵育后也显示出同样的条带加倍现象。这一发现可能反映出血红蛋白与葡萄糖之间初始缩合产物即席夫碱中间体的存在。
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