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特发性肺纤维化中的呼吸功能损害:特别强调小气道的明显阻塞体征(作者译)

[Respiratory function impairment in idiopathic pulmonary fibrosis: with special emphasis on the apparently obstructive signs of small airways (author's transl)].

作者信息

Minami Y

出版信息

Hokkaido Igaku Zasshi. 1980 May;55(3):251-65.

PMID:7450671
Abstract
  1. Respiratory function tests were performed in 6 cases with idiopathic pulmonary fibrosis (IPF) and 10 cases with pulmonary fibross associated with collagen disease. Obtained results were as follows: 2) In IPF, maximum mid-expiratory flow rate (MMF), maximal expiratory flows at 50 per cent (V50) and at 25 per cent (V25) of vital capacity significantly decreased, but no abnormal values was obtained in dynamic compliance test and multibreath N2 washout test. 3) The single model analysis of the lung functions suggested that the decrease of MMF, V50 or V25 in IPF was possibly resulted from the decrease of vital capacity. 4) These results suggest that the decrease of MMF, V50 or V25 observed in IPF is not the sign of the obstructive abnormalities in small airways, but the secondary sign caused by limitation of the lung volume.
摘要
  1. 对6例特发性肺纤维化(IPF)患者和10例胶原病相关的肺纤维化患者进行了呼吸功能测试。结果如下:2) 在IPF中,最大呼气中期流速(MMF)、肺活量50%时的最大呼气流量(V50)和25%时的最大呼气流量(V25)显著降低,但动态顺应性测试和多次呼吸氮洗脱测试未获得异常值。3) 肺功能的单模型分析表明,IPF中MMF、V50或V25的降低可能是由于肺活量降低所致。4) 这些结果表明,IPF中观察到的MMF、V50或V25的降低不是小气道阻塞性异常的征象,而是肺容积受限引起的继发性征象。

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