循环儿茶酚胺对胎羊心血管系统的影响。

The cardiovascular effects of circulating catecholamines in fetal sheep.

作者信息

Jones C T, Ritchie J W

出版信息

J Physiol. 1978 Dec;285:381-93. doi: 10.1113/jphysiol.1978.sp012577.

DOI:10.1113/jphysiol.1978.sp012577

PMID:745099

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1281762/

Abstract

Adrenaline and noradrenaline have been infused into the fetal sheep to produce plasma concentrations comparable to those seen during hypoxia and the cardiovascular changes compared with those seen in response to hypoxia. The effect of isoprenaline, methoxamine, and beta- and alpha-adrenergic antagonists were also investigated. 2. There were no significant changes in the blood gas values during any of the infusions except for a mean fall in pH of 0.04 during adrenaline infusion. 3. Adrenaline caused a fall in the fetal heart rate followed by a rise above the control value after 15-20 min. The fall in heart rate was abolished when the rise in blood pressure was blocked with phentolamine. The rise in heart rate was blocked by propranolol. The exact cause of the biphasic changes in heart rate during adrenaline infusion is not clear. 4. A fall in heart rate was not seen with noradrenaline; a small rise was. Propranolol changed this into a fall in heart rate while phentolamine increased the size of the heart rate rise. 5. Phentolamine alone increased the fetal heart rate by 25% and reduced blood pressure by 12%; propranolol alone reduced heart rate by 14% and had no effect on blood pressure. Isoprenaline increased fetal heart rate and reduced blood pressure. 6. The incidence of fetal breathing movements was highly variable. Despite this a significant increase was observed during adrenaline infusion. None of the other infusions had consistent effects. 7. The role of the circulating catecholamines in mediating or modifying the cardiovascular responses to hypoxia in the fetal sheep is discussed.

摘要

已将肾上腺素和去甲肾上腺素注入胎羊体内，以产生与缺氧时相当的血浆浓度，并将心血管变化与缺氧时的变化进行比较。还研究了异丙肾上腺素、甲氧明以及β和α肾上腺素能拮抗剂的作用。2. 除肾上腺素输注期间pH值平均下降0.04外，其他任何输注期间血气值均无显著变化。3. 肾上腺素使胎心率下降，15 - 20分钟后升至对照值以上。当用酚妥拉明阻断血压升高时，心率下降被消除。心率升高被普萘洛尔阻断。肾上腺素输注期间心率双相变化的确切原因尚不清楚。4. 去甲肾上腺素未引起心率下降，而是有小幅上升。普萘洛尔将此转变为心率下降，而酚妥拉明则增加了心率上升的幅度。5. 单独使用酚妥拉明可使胎心率增加25%，血压降低12%；单独使用普萘洛尔可使心率降低14%，对血压无影响。异丙肾上腺素增加胎心率并降低血压。6. 胎儿呼吸运动的发生率变化很大。尽管如此，在肾上腺素输注期间观察到显著增加。其他输注均未产生一致的效果。7. 讨论了循环儿茶酚胺在介导或改变胎羊对缺氧的心血管反应中的作用。