慢性二尖瓣关闭不全时的心脏细胞内及血液电解质

Cardiac intracellular and blood electrolytes in chronic mitral insufficiency.

作者信息

Khatter J C, Singal P K, Bharadwaj B, Prasad K

出版信息

J Physiol (Paris). 1978 Dec;74(6):535-40.

Abstract

A study of the alterations in the intracellular electrolytes in the left failing heart due to induced mitral insufficiency was made in dogs. The extracellular space increased significantly. There was no significant change in the plasma Na+ and Ca++. However, there was a significant decrease in the plasma K+. The ratio of wet weight to dry weight increased during mitral insufficiency, although not significantly. There were no significant changes in the tissue Na+, K+ and Ca++. However, there were significant decreases in the intracellular Na+ and Ca++, and tendency for an increase in the intracellular K+ during mitral insufficiency. These results suggest that the decrease in the myocardial contractility in chronic heart failure due to mitral insufficiency might be due to a decrease in the intracellular Ca++ and associated changes in Na+ and K+ as a result of increased sarcolemmal ATPase.

摘要

对因诱导性二尖瓣关闭不全导致左心衰竭的犬类细胞内电解质变化进行了一项研究。细胞外间隙显著增加。血浆Na⁺和Ca²⁺无显著变化。然而，血浆K⁺显著降低。二尖瓣关闭不全期间，湿重与干重之比增加，尽管不显著。组织Na⁺、K⁺和Ca²⁺无显著变化。然而，二尖瓣关闭不全期间，细胞内Na⁺和Ca²⁺显著降低，细胞内K⁺有增加趋势。这些结果表明，二尖瓣关闭不全导致的慢性心力衰竭中心肌收缩力下降可能是由于细胞内Ca²⁺减少以及由于肌膜ATP酶增加导致的Na⁺和K⁺相关变化。