Greenhalgh R M, Laing S, Taylor G W
J Cardiovasc Surg (Torino). 1980 Sep-Oct;21(5):559-67.
Hyperlipoproteinaemia is an important risk factor in extracranial arterial disease and the mean values of serum triglyceride and serum cholesterol were raised in a group of 43 patients with carotid stenosis. The risk factors for carotid stenosis are not unlike those for other types of atherosclerotic disease such as dilating arterial disease. Serum triglyceride and cholesterol levels in a group of 22 patients with intracranial aneurysms are similar to those of age and sex matched control patients and are significantly lower than those of a group of 69 patients with dilating arterial disease. It is suggested that the aetiology of these two aneurysmal diseases may be different. 55% of the patients with intracranial aneurysms were hypertensive and only 50% were heavy smokers. This is a much lower incidence of cigarette smoking than in patients with either carotid stenosis or dilating disease. We conclude that intracranial aneurysms are unlikely to be caused by atherosclerosis.
高脂蛋白血症是颅外动脉疾病的一个重要危险因素，在一组43例颈动脉狭窄患者中，血清甘油三酯和血清胆固醇的平均值升高。颈动脉狭窄的危险因素与其他类型的动脉粥样硬化疾病（如扩张性动脉疾病）的危险因素并无不同。一组22例颅内动脉瘤患者的血清甘油三酯和胆固醇水平与年龄和性别匹配的对照患者相似，且显著低于一组69例扩张性动脉疾病患者。提示这两种动脉瘤性疾病的病因可能不同。55%的颅内动脉瘤患者患有高血压，只有50%是重度吸烟者。这一吸烟发生率远低于颈动脉狭窄或扩张性疾病患者。我们得出结论，颅内动脉瘤不太可能由动脉粥样硬化引起。
