Foster A C, Roberts P J
J Neurochem. 1980 Aug;35(2):517-9. doi: 10.1111/j.1471-4159.1980.tb06299.x.
The release of six endogenous amino acids from superfused rat cerebellar slices was investigated. Only L-glutamate, and GABA exhibited a calcium-dependent, potassium-stimulated release. Glutamine release was significantly inhibited during the stimulation period. Experiments were also performed with slices from cerebella which had received previously, injections of 2 micrograms kainic acid. This procedure failed to modify the release of any amino acid. At this time point (24 h), cell bodies of inhibitory neurons utilising GABA as their transmitter, have largely been destroyed; thus, the lack of effect on GABA release in particular, may indicate that the mechanisms for transmitter release from terminals are still operative under these conditions.
研究了从灌流的大鼠小脑切片中释放的六种内源性氨基酸。只有L-谷氨酸和GABA表现出钙依赖性、钾刺激释放。在刺激期间谷氨酰胺释放受到显著抑制。还对先前接受过2微克 kainic 酸注射的小脑切片进行了实验。该操作未能改变任何氨基酸的释放。在这个时间点（24小时），利用GABA作为递质的抑制性神经元的细胞体已大部分被破坏；因此，特别是对GABA释放缺乏影响，可能表明在这些条件下终末递质释放机制仍然有效。
