Braunitzer G
Klin Wochenschr. 1980 Jul 15;58(14):701-8. doi: 10.1007/BF01478457.
The perinatal control of the oxygen affinity of human blood and the high altitude respiration of the llama is discussed. Furthermore, the sequences of the beta-chains of the hemoglobin of man, llama, dromedary and the gamma-chains of human fetal hemoglobin are reported. Considering physical, physiological, and chemical data it is shown that the human fetal respiration and the high altitude respiration of llama are based on a similar molecular mechanism and are marked by a reduced mutual effect of the non alpha-chains to 2,3-bisphosphoglycerate. The reduced mutual effect is interpreted as a mutation and interruption of the phosphate contacts in gamma 143 Serin at the fetus and beta 2 Asparagin at the llama resulting in an increased oxygen affinity of the corresponding hemoglobins. The respiration of the fetus and that of the llama in the Andes is thereby molecularly interpreted.
讨论了人类血液氧亲和力的围产期控制以及羊驼的高原呼吸。此外，还报告了人类、羊驼、单峰驼血红蛋白β链以及人类胎儿血红蛋白γ链的序列。综合物理、生理和化学数据表明，人类胎儿呼吸和羊驼的高原呼吸基于相似的分子机制，其特点是与2,3-二磷酸甘油酸的非α链相互作用减弱。这种减弱的相互作用被解释为胎儿γ143丝氨酸和羊驼β2天冬酰胺处磷酸盐接触的突变和中断，导致相应血红蛋白的氧亲和力增加。从而从分子角度解释了胎儿呼吸和安第斯山脉羊驼的呼吸。
