Weidmann P
Klin Wochenschr. 1980 Oct 1;58(19):1071-89. doi: 10.1007/BF01476878.
The sympathetic system, the body sodium-fluid volume state, the renin-angiotensin system, functional and structural characteristics of the heart and blood vessels, and some other components are important complementary factors in blood pressure regulation. A deviation from the normal equilibrium among these components, with a persisting non-physiologic increase in pressor factor(s) or in the basal vascular tone and/or cardiovascular reactivity to pressor factors, leads to hypertension. This review discusses recent observations and concepts regarding the pathogenesis of essential hypertension and hypertension associated with diabetes mellitus. It focuses on the roles of various pressor factors as well as cardiovascular pressor responsiveness in the genesis of high blood pressure and in the antihypertensive mechanism of diuretic treatment.
交感神经系统、机体钠-液容量状态、肾素-血管紧张素系统、心脏和血管的功能及结构特征，以及其他一些因素是血压调节中的重要补充因素。这些因素之间偏离正常平衡，若升压因子或基础血管张力持续出现非生理性升高和/或心血管对升压因子的反应性增强，就会导致高血压。本综述讨论了关于原发性高血压和糖尿病相关高血压发病机制的最新观察结果和概念。它重点关注各种升压因子的作用以及心血管升压反应性在高血压发生和利尿剂治疗降压机制中的作用。
