Ghezzi P M, Di Siena F, Palanca R, Dutto A, Cento G
Minerva Med. 1980 Oct 27;71(41):2987-91.
A sequential real-time study was run to monitor plasma heparin values following three standard dose protocols during 4-hr dialysis, using an enzymatic method. One group of patients was given a single dose of 7000 IU at the commencement of dialysis, a second group 5000 IU at the start and 2500 IU at the end of the third hour, and a third group 2500 IU at the start and 1500 UI/hr for four hours. Plasma levels were checked every hour and ranged from 0.702 IU/ml (+/- 0.069) (start) to 0.290 IU/ml (+/- 0.079) (end) in the first group, 0.552 (+/- 0.116) to 0.312 (+/- 0.09) in the second, and 0.456 (+/- 0.113) to 0.314 (+/- 0.063) in the third. Correlation of heparin levels with coagulation time led to the establishment of an optimal range of 0.2 to 0.6 IU/ml.
采用酶法进行了一项序贯实时研究，以监测4小时透析期间三种标准剂量方案后的血浆肝素值。一组患者在透析开始时给予7000 IU的单次剂量，第二组在开始时给予5000 IU，在第三小时结束时给予2500 IU，第三组在开始时给予2500 IU，并在4小时内以每小时1500 UI的速度给药。每小时检查血浆水平，第一组从0.702 IU/ml（±0.069）（开始）到0.290 IU/ml（±0.079）（结束），第二组从0.552（±0.116）到0.312（±0.09），第三组从0.456（±0.113）到0.314（±0.063）。肝素水平与凝血时间的相关性导致确定了0.2至0.6 IU/ml的最佳范围。
