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通过体外实验测定选定软膏基质中药物的可用性。第4部分：局部麻醉药庚卡因的释放（作者译）

[Determination of the availability of drugs from selected ointment bases by means of in vitro experiments. Part 4: The release of the local anaesthetic heptacaine (author's transl)].

作者信息

Szücsová S, Cizmárik J, Michalov J

出版信息

Pharmazie. 1980;35(10):625-6.

PMID:7454744
Abstract

The velocity of the release of heptacaine from selected ointment bases of the Csl. L. III has been studied in vitro with the aid of a dialysis technique. At three constant times the release rate could be brought in relation to the type of ointment base. Furthermore, the particle size of the suspended drug was estimated. It was found that the velocity of the release of heptacaine is influenced by its solubility in the outer phase of the ointment base.

摘要

借助透析技术，在体外研究了七卡因从选定的III类软膏基质中释放的速度。在三个固定时间点，释放速率可与软膏基质的类型相关联。此外，还对悬浮药物的粒径进行了估算。结果发现，七卡因的释放速度受其在软膏基质外相中的溶解度影响。

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