A study on the release of prednisone from new ointment bases containing various additives.

The effect of various additives on the release of prednisone from new ointment bases, was investigated. It was found that the rate of release of prednisone was greater from the oil in water emulsion ointment base that both the water in oil or oleagenous bases. The incorporation of water in the water in oil emulsion base decreased the rate of diffusion of prednisone than any of the other additives used. It was also concluded that the best release of prednisone was obtained from the bases which were of similar nature to the diffusion medium. Other factors such as the characteristics of bases and the additives as well as their effect upon the solubility of the drug in the mixture may play a part.