Attia M A, Aboutaleb A E, Habib F S
Pharmazie. 1981;36(1):21-3.
The effect of various additives on the release of prednisone from new ointment bases, was investigated. It was found that the rate of release of prednisone was greater from the oil in water emulsion ointment base that both the water in oil or oleagenous bases. The incorporation of water in the water in oil emulsion base decreased the rate of diffusion of prednisone than any of the other additives used. It was also concluded that the best release of prednisone was obtained from the bases which were of similar nature to the diffusion medium. Other factors such as the characteristics of bases and the additives as well as their effect upon the solubility of the drug in the mixture may play a part.
研究了各种添加剂对泼尼松从新型软膏基质中释放的影响。结果发现，泼尼松从水包油乳剂软膏基质中的释放速率比油包水或油脂性基质中的释放速率更快。在油包水乳剂基质中加入水，比使用的任何其他添加剂都降低了泼尼松的扩散速率。还得出结论，从与扩散介质性质相似的基质中可获得泼尼松的最佳释放效果。其他因素，如基质和添加剂的特性以及它们对药物在混合物中溶解度的影响，可能也起作用。
